Remember, when people tell you the science is "settled", they are telling you to shut up.
So, carry on!
"On April 8, 1906, after nearly five years of progressive mental and physical decline, Auguste died. The official cause of death was blood poisoning due to bedsores. Dr. Alzheimer suspected that behind her mental illness was a strange disease, and that perhaps examining her brain would offer some clues. When he examined the brain sections under the microscope, his suspicion was confirmed. Dr. Alzheimer described changes in the neurofibrils - the protein filaments found in brain cells. He also saw peculiar deposits that he referred to a “millet seed-sized lesions.” These pathologic findings - now known as neurofibrillary tangles and amyloid deposits - characterize the brains of Alzheimer's Disease patients."
"Dr. Alzheimer's discovery was not immediately well received. In fact, the first time he presented Auguste's case and autopsy findings during a German Psychiatry conference in 1906, the reception from the audience was rather cold."
"This was the time when psychoanalysis and the Freudian views on the relationship between childhood trauma and mental illness were, in today's parlance, the “trending” topics in psychiatry."
"Correlating mental or neurologic disorders with histopathologic findings was not yet firmly established nor accepted. Ninety years later, in 1998, researchers re-examined Auguste's original brain sections and confirmed the presence of neurofibrillary tangles and amyloid plaques."
"On April 8, 1906, after nearly five years of progressive mental and physical decline, Auguste died. The official cause of death was blood poisoning due to bedsores. Dr. Alzheimer suspected that behind her mental illness was a strange disease, and that perhaps examining her brain would offer some clues. When he examined the brain sections under the microscope, his suspicion was confirmed. Dr. Alzheimer described changes in the neurofibrils - the protein filaments found in brain cells. He also saw peculiar deposits that he referred to a “millet seed-sized lesions.” These pathologic findings - now known as neurofibrillary tangles and amyloid deposits - characterize the brains of Alzheimer's Disease patients."
"Dr. Alzheimer's discovery was not immediately well received. In fact, the first time he presented Auguste's case and autopsy findings during a German Psychiatry conference in 1906, the reception from the audience was rather cold."
"This was the time when psychoanalysis and the Freudian views on the relationship between childhood trauma and mental illness were, in today's parlance, the “trending” topics in psychiatry."
"Correlating mental or neurologic disorders with histopathologic findings was not yet firmly established nor accepted. Ninety years later, in 1998, researchers re-examined Auguste's original brain sections and confirmed the presence of neurofibrillary tangles and amyloid plaques."
